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Development of Cardiomyopathy in Female Carriers of Duchenne and Becker Muscular Dystrophies JAMA 275:1335-1338, Politano,L.,et al, 1996 See this aricle in Pubmed Article Abstract Preclinical or clinically evident myocardial involvement was found in 166 cases(84.3%),without significant differences in percentage and behavior between DMD and BMD carriers.Its occurrence increased significantly with age,from 54.5%(18 cases)in carriers aged between 5 and 16 years to 90.2% (147 cases)in carriers older than 16 years.Dystrophin anomalies were detected at the membrane level of the myocardial fibers in all endomyocardial biopsy specimens.Genetic anomalies can be considered the primary cause of myocardial damage in carriers of dystrophinopathic myopathies;myocardial damage shows the same behavior already described in DMD and BMD patients and progresses from preclinical to dilated cardiomyopathy,passing through stages of myocardial hypertrophy or dysrhythmias.

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(click to filter results - removes previous filter) arrhythmia,cardiac cardiomyopathy dystrophin muscular dystrophy muscular dystrophy,Becker muscular dystrophy,Becker,carrier muscular dystrophy,cardiovascular changes with muscular dystrophy,Duchenne muscular dystrophy,Duchenne,carrier

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